Lesson #6:
Allergies:
Our Over Reacting Immune system
Lesson #6:
Allergies:
Our Over Reacting Immune system
Students will be able to describe how the immune system over reacts to the antigen on usually harmless substances which causes an allergic reaction.
Explain the role of antibodies and Mast Cells in allergic reactions
Describe how the immune system misidentifies harmless allergens and over reacts
Apply my knowledge of allergic reactions to explain how anti-histamine medicines work.
HS-LS1-2: Develop and use a model to illustrate the hierarchical organization of interacting systems that provide specific functions within multicellular organisms.
Reminders:
Immune System End of Unit Exam on Thursday, March 12th
PTC on Wednesday March 18th and Thursday March 19th
Part #1
Warm-Up
Spot the Difference!
(10 min)
Directions:
Read the question below.Then read student A and student B's responses. Evaluate their responses by answering the questions below:
1) Which student response is wrong?
2) Explain why it is wrong.
3) What specifically could the student have done to improve their response?
(Be VERRRYYY Detailed)
Base your answers to the following questions on the information below and on your knowledge of biology.
The hedgehog, a small mammal native to Africa and Europe, has been introduced to the United States as an exotic pet species. Scientists have found that hedgehogs can transfer pathogens to humans and domestic animals. Foot-and-mouth viruses, Salmonella, and certain fungi are known pathogens carried by hedgehogs. As more and more of these exotic animals are brought into this country, the risk of infection increases in the human population.
Explain in detail how the human immune system might respond to an invading pathogen associated with handling a hedgehog.
If the invading pathogen is able to get through the skin, hair and mucus, then the macrophages that patrol the blood will attempt to engulf them. But, if the macrophages do not recognize the antigen on the pathogen, then the pathogen will be able to reproduce and the person will get sick. Eventually, the white blood cells will remember the shape of the antigen and make antibodies that fit with it, like a lock and key. The pathogen will then be marked for destruction.
If the pathogen gets into the person's body then their immune system will try to fight it. Their immune system will make antigens that fight the pathogen. If the person gets sick in the future, the antigens will remember how they were really ill and try to stop the pathogen with antibiotics that are the right shape. Therefore, in my opinion, you shouldn't have guinea pigs.
Part 2:
French? or Dutch?
Cross Cutting Concepts
(5 min)
The year is 1812 and you are the captain of a British warship at sea. Britain is at war with France, so your crew is watching carefully for enemy ships. Suddenly, someone spots a ship on the horizon. Your crew sees the flag and believes it is a French ship! They ring the alarm, muster the crew, draw their swords and quickly fire the cannons. Ka- Boom!
Later, you realize the ship was actually flying a Dutch flag, and the Dutch are not your enemy but a friend.
Turn and talk:
What mistake did the British ship make? How is this similar to what happens during an allergic reaction in the immune system? (Hint: What is the flag like?)
Part 3:
Mid-Point Check
(2 min)
Carmine, a compound that comes from the cochineal beetle, shownto the right, is used as a food coloring.
The food coloring is not harmful to most people, but in a small number of individuals, it causes a reaction and affects their ability to breathe. This response to carmine is known as
A. a stimulus
B. an allergy
C. natural selection
D. an adaptation
Part 4:
Active Reading
(10 min)
Directions:
1 person read each paragraph out loud
Answer the assigned question in your group
Allergies occur when the immune system overreacts to a substance that is normally harmless. These harmless substances are called allergens. Common allergens include pollen, dust, pet dander, and certain foods. Even though these substances are not dangerous to most people, the immune system of someone with allergies treats them as if they are harmful antigens, which are molecules the immune system recognizes as foreign.
When an allergen enters the body, the immune system may produce special antibodies that recognize the allergen’s antigen. These antibodies attach to the surface of certain white blood cells called mast cells. Mast cells are found in many body tissues, especially in areas that come into contact with the outside environment, such as the skin, nose, and lungs. Their role is to help the body quickly respond when something foreign enters the body.
If the same allergen enters the body again, it can bind to the antibodies on the mast cells. This signals the mast cells to react quickly. Inside these white blood cells are small packets of histamine, which can be thought of as a chemical “bomb”. When the allergen binds to the antibodies, the mast cells release this histamine bomb into the surrounding tissues.
The release of this histamine bomb causes many of the symptoms people experience during an allergic reaction. Histamine can cause blood vessels to widen, tissues to swell, and mucus to be produced. These effects lead to symptoms such as sneezing, itchy eyes, a runny nose, difficulty breathing and swelling. Even though allergens are usually harmless, the immune system reacts strongly because it mistakenly treats the allergen’s antigens as a serious threat.
Explain the sequence of events that occurs from the moment an allergen enters the body for the second time to the point when allergy symptoms appear. Include the roles of antibodies, mast cells, and histamine in your answer. (Hint: Use picture below for help)
Scientists are developing a new medication that prevents mast cells from releasing histamine.
Explain how this medication would most likely affect the symptoms of an allergic reaction. Use information from the article and your knowledge of biology to support your answer.
Part 5:
TN'T x 3
(10 min)
Número Uno
Turn and discuss what happens in the body during an allergic reaction
Número Dos
Turn and discuss what happens in the body during an allergic reaction using the Tier 2 (general) and Tier 3 (Biology specific) Vocabulary you come up with: ➡️
Número Tres
Using the conjunctions "Although", "While" and "If" Turn and discuss what happens in the body during an allergic reaction
**Remember to use the Tier 2 (general) and Tier 3 (Biology specific) vocabulary in your conjunction sentences.**
Sneeze
Cough
Inflammation
Bind
Mistake
Misidentify
Allergen
Antigen
Antibody
White Blood Cells
Pathogen
Immune System
Histamine
Part 6
Stop n' Jot
(3 min - Left Side)
Key Concepts:
Allergies are caused by the immune system over reacting to a harmless allergen (peanuts, tree nuts, pollen, cat hair, etc).
The immune system makes antibodies that bind to the antigens on the allergen.
Then, white blood cells called Mast Cells, release histamines (type of chemical) which causes allergic reaction symptoms: runny nose, swelling, itchy eyes/skin etc.
Allergen: Antigens that trigger allergies.
Histamine: Chemical that causes allergy symptoms like itching, swelling, sneezing or even trouble breathing.
Mast Cells: White blood cells that store histamines and have antibodies on the surface. They cause the allergic reaction.
Part 6:
Check for Understanding
(2 min)
Many adults lack the ability to digest the milk sugar, lactose. Often, this is due to the insufficient production of the enzyme lactase, which breaks down lactose. This is not due to an allergy to milk. Milk allergies are different because they
1. are often not harmful to the person
2. result in a build-up of the substance in the body
3. are the result of the digestive system attacking the substance
4. result from an overreaction of the immune system to a harmless substance