Lesson 12:
Endocrine System
Embedded Files
EOU Exam on Thursday, May 1st
Learning Intention:
Explore the endocrine system through tiered texts and apply my knowledge to new situations concerning new weight loss medications
Success Criteria:
I am successful when I can...
Analyze and judge student responses to past regents questions.
Engage in clichés about teenage behavior by discussing with peers.
Explore the endocrine system by actively reading an article and creating annotations.
Explain the endocrine system is vital to new real-world medications, such as Ozempic.
Elaborate by applying my knowledge of the endocrine system to regents-esque questions about Ozempic.
Standards:
HS-LS1-2.
Develop and use a model to illustrate the hierarchical organization of interacting systems that provide specific functions within multicellular organisms.
Reminders:
Tutoring Thursdays from 1:50 to 3:50 in A-301.
Body systems exam moved to Friday 10/25 from Thursday 10/24
Medical Journal collected and graded next Monday
Part 1
Warm-Up
Something Looks Sus'
(5 min)
Question #1
Question #1
Question #2
Question #2
Question #3
Question #3
Circulatory
Digestive
Respiratory
Excretory
Student Response #1
Student Response #1
1) The digestive system breaks down organic molecules into their building blocks so cells can use them to maintain homeostasis.
2) The circulatory system carries molecules needed by the body's cells, such as oxygen, glucose and amino acids so that the cells can continue their processes and maintain homeostasis.
Student Response #2
Student Response #2
Diffusion occurs in the small intestine. Glucose diffuses from the small intestine, through the villi and into the blood.
Student Response #3
Student Response #3
One possible malfunction of the circulatory system is a heart attack . The malfunction could be prevented by eating healthy.
Part 2
Hooked on Hormones
Turn n' Talk #1
(5 min)
Movies often show teenagers as impulsive and out of control. As a teenager, do you agree with this portrayal?
Is there a scientific reason that may explain why teens sometimes act this way?
Discuss your thoughts at your tables.
Part 3
Active Reading
Endocrine System
(10 min)
We know that teenagers may act wildly because of raging hormones, but that is not the only thing hormones do. They help control a lot of processes in our bodies by acting as messengers. Lets find out more about these amazing hormones.
Directions:
1) Actively read one of the resources below.
2) Write five (5) annotations as you read.
Part 4
Stop n' Jot
(5 min)
Purpose:
Glands secrete (release) hormones
Hormones are chemical messengers that travel through the blood to "target" cells and tell them to do something specific.
Hormones affect metabolism, growth, development, emotions, fertility, sexual function, sleep and blood pressure.
Hormones only work on target cells if they have the complimentary shaped receptor.
Glands and Hormones you need to know:
1) Ovaries secrete estrogen
2) Testes secrete testosterone
3) Pancreas secretes insulin
Part 5
Turn n' Talk
(2 min)
Have you heard about a new medicine called Ozempic?
What does it do and how do you think it works?
(hint: hormones)
Part 5
Exit Ticket
(5 min)
Scenario: The Shape of GLP-1 and Its Role in Diabetes Treatment
Scenario: The Shape of GLP-1 and Its Role in Diabetes Treatment
A new diabetes treatment involving a hormone called GLP-1 has recently gained attention. These medications have a similar molecular shape to GLP-1 (glucagon-like peptide-1), which helps regulate blood sugar levels. GLP-1 binds to specific receptors on cells in the pancreas, triggering the release of insulin, which lowers blood sugar by promoting the uptake of glucose into cells.
The key to this process is the specific shape of the GLP-1 molecule. The hormone must have the correct shape to bind to the GLP-1 receptor, much like a key fitting into a lock. If the GLP-1 molecule’s shape is altered, it may no longer fit into the receptor, preventing it from triggering insulin release.
Scientists have been working to design synthetic GLP-1 molecules that maintain the correct shape for receptor binding while lasting longer in the bloodstream. However, some patients have reported side effects, such as reduced appetite and slower digestion. This is because GLP-1 receptors are also found in the brain and digestive system, where they play roles in controlling hunger. The interaction between the shape of GLP-1 and its receptors in different parts of the body helps explain these varied effects.
As researchers continue to study GLP-1 medications, they aim to refine the treatment to maximize its benefits while minimizing side effects. Understanding the relationship between the hormone’s shape and receptor function is key to improving future therapies.
Multiple Choice Questions:
Multiple Choice Questions:
Why is the shape of the GLP-1 molecule important for its function in the body?
a) It allows the hormone to circulate through the bloodstream without being broken down.
b) It ensures that GLP-1 can be absorbed directly into the pancreas.
c) It allows GLP-1 to bind to specific receptors on the cells of target organs.
d) It prevents the hormone from being released by the pancreas.What would most likely happen if the shape of a GLP-1 molecule were altered?
a) It would bind more effectively to all types of cells.
b) It would no longer fit into the GLP-1 receptors, reducing its effectiveness.
c) It would increase the body’s production of insulin.
d) It would increase glucose levels in the bloodstream.
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