Lesson #4:
Pathogenic Mutations / Vaccines
Embedded Files
EOU Exam on Thursday, May 1st
Learning Intention:
Learning Intention:
Students will be able to model how antibodies protect us from disease and how pathogens fight back by mutating.
Success Criteria:
Success Criteria:
I am successful when I can...
Identify how the immune system protects us from disease
Explain how the antibody-antigen reaction is specific
Model how antibodies connect to antigens depending upon shape.
Model how pathogens can modify their antigens through mutations.
Explain how vaccines prepare our body for the actual pathogen.
Agenda:
Agenda:
1) Spot the Difference
2) Clay Model
3) TN'T x 3
4) Search & Unseen
5) Close-Out
Reminders:
Reminders:
Vocab Quiz on Thursday February 6th
Practice Regents #2 due Wednesday 2/12
Pathogenic Mutations and Vaccines_ A Science Lesson.wavPart 1
Spot the Difference
Warm-Up
(5 min)
Directions:
Step 1) Read the question below
Step 2) Read both, Student A and Student B's response.
Step 3) In your medical journal, identify which student's response is more likely to get points. Describe in detail why their response is better.
Student A
Student A
The tumor cells get ignored because the immune system doesn’t do anything to them. The immune system doesn’t do anything because the cells are ignored. The devils get sick because the immune system isn’t fighting. If the immune system fought, they wouldn’t get sick. But it doesn’t fight, so they get sick. That’s why the cancer happens. It’s like their body just lets it happen because it’s not stopping it.
Student B
Student B
The tumor cells have antigens nearly identical to the host Tasmanian devil’s own cells, so the immune system doesn’t recognize them as foreign. Because the immune system doesn't detect foreign antigens, no antibodies are made to attack the tumor cells, allowing the cancer to spread unchecked.
Part #2
Mutation Modeling Activity
(10 min)
Directions:
Students at odd number desks - use the clay to design a pathogen (don't forget the antigens).
Students at even number desks, design an antibody that can fight that pathogen.
Question:
How could the pathogen "hide" itself so the antibody no longer works on it?
This is called a......
This is called a......
Mutation:
Antigens on the pathogen randomly change shape because of an error when replicating.
Part 3
Turn n' Talk
Numero Uno
(2 min)
Question:
How could the pathogen "hide" itself so the antibody is no longer effective on it?
Part 4
Turn n' Talk
Numero Dos
(2 min)
How could the pathogen "hide" itself so the antibody is no longer effective on it?
Tier 2
Specific
Shape
Change
Bind
Ineffective
Tier 3
Lock and Key
Protein
Antigen
Antibody
Pathogen
Mutation
Part 5
Turn n' Talk
Numero Tres
(5 min)
Use the conjunctions because, but and so to answer the question:
How could the pathogen "hide" itself so the antibody is no longer effective on it?
Because = Cause and Effect
But = Difference
So = Consequence
Sentence Starters:
1) Pathogens change the shape of their antigens because......
2) The antibodies might not connect to the antigens but......
3) The antibodies can't bind to the new shape so......
Part 6
Search & Unseen Cengage Reading
Search Question
Search Question
Why was the practice of using cowpox sores for immunization against smallpox initially met with resistance, and what evidence eventually supported its effectiveness?
Unseen Question
Unseen Question
Based on the information about Edward Jenner's discovery, explain why antibodies produced during a cowpox infection protect against smallpox. How does this principle apply to the development of modern vaccines?
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