Science - Lesson #2: Lines of Defense

EOU Exam on Thursday, May 1st

Science

Lesson #2:

Innate and Adaptive Lines of Defense

Learning Target:

Explore the different levels of the immune system and apply my knowledge to a new scenario.

Success Criteria:

I am successful when I can...

1) Identify and describe the three lines of defense in the immune system.

2) Describe the components of each line of defense

3) Explain the function of each line of defense

4) Apply my knowledge of the immune system to a new scenario

Standards:

HS-LS1-2: From Molecules to Organisms: Structures and Processes

Standard: Develop and use a model to illustrate the hierarchical organization of interacting systems that provide specific functions within multicellular organisms.

Reminders:

Practice Regents #2 Due February 12th

Medical Journal

Warm-Up:

Spot the Difference

(5 min)

Directions: Please write this on the left hand page of your medical journal, after copying the Lesson # and Lesson Title.

Which student response is incorrect?

Explain in detail why it is incorrect.

3 sentence minimum.

Student A's Response

I infer that Plasmodium is a parasite because it lives inside humans, in the liver and blood cells. It stays there and uses the human’s body to make more of itself. Parasites are just things that live inside other organisms

Student B's Response

Plasmodium is a parasite because it depends on humans for survival and harms them. It invades liver and red blood cells, feeds on the host’s resources, and causes damage when the cells burst. A parasite hurts the host while benefiting by stealing resources.

Part 1 (5 min)

Turn and Talk

Two Hundred students use this room everyday. There are trillions of pathogens living on the classroom floor, carried inside by these students (and teachers). Wanting to impress his students and show them how much of a rebel he is, Mr. Pinho rolls around on the floor. He doesn't get sick.

Question: Why didn't Mr. Pinho get sick if he touched these trillions of pathogens?

Part 2 (10 min)

Active Reading / Annotations

Directions:

Actively read the article by making 6 (SIX) annotations:

2 Connections 💭 between the text and your life, movies, books, class etc

2 Main Ideas 💡 Paraphrased in your own words

2 Questions ❓

**FOLLOW THE ANNOTATION RUBRIC AT YOUR DESK!**

IMMUNITY AND DEFENSE

Part 3 (10 min)

Two Box Induction

HINT: What does each column focus on fighting?

Part 4

Application to

Maria Lopez

(5 min)

As you know, doctors are considering giving Maria Lopez a pig kidney to replace her nonfunctional kidneys. Maria's kidneys were badly damaged when she became infected by Malaria as a baby. Malaria is a parasite that is transmitted by mosquitos. Malaria can damage the kidneys by causing inflammation and impairing blood flow. This can lead to acute kidney injury (AKI) and chronic kidney disease.

Directions: On the right hand page of the medical journal, describe in your own words how Maria's body fought off the parasite. Be sure to mention the immune systems different levels of defense. Start with the first line of defense: the skin. (4 sentence minimum)

Part 5

Stop n' Jot

(5 min)

1st Line of Defense

(Non-Specific)

Prevents pathogens from entering the body by blocking them or trapping them outside.

Includes:

1) Skin

2) Mucous

3) Hair

2nd Line of Defense

(Non-Specific)

White blood cells eat pathogens that enter the body. Causes symptoms to occur such as sneezing and coughing

Includes:

1) White blood cells (Macrophage)

3rd Line of Defense

(Specific)

Antibody binds/connects to the surface of a antigen . The antibody marks the pathogen for destruction, preventing the pathogen from penetrating healthy cells.

Includes:

1) Antigens

2) Killer T Cells

3) B Cells

1) Antigen - Located on the surface of pathogens. Acts as a flag, telling our white blood cells whether this object belongs in our body or should be destroyed.

2) White Blood Cells - fights pathogens in the body.

3) Immune Response - results in the symptoms of a disease in response to an antigen. Example - Dog having itchy skin and inflammation due to the saliva of a flea

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